EGFR and metastatic malignant neoplasm in the lymph nodes: Jiang et al. showed the positive rate of pSTAT3 expression in patients with lymph node metastasis was 78.8% (41/52), which was significantly higher than that in NSCLC patients with non-lymph node metastasis (54.7%, 41/75) using immunohistochemical staining among the 127 cases of p-STAT3 immunoreactivity, was significantly correlated with sex (p = 0.004), smoking history (p = 0.006), EGFR mutation status (p = 0.003), clinical stage (p = 0.034), and lymph node metastasis (p = 0.009) [3].