While STAT activation is strictly controlled in normal cells and plays a key role in multiple cellular functions, such as cell growth and differentiation, metabolism, hematopoiesis, host defense and immunoregulation, the durable activation of tyrosine kinases in malignant tumor causes constitutive activation of STATs, particularly STAT3 and STAT5 [10,18,20]. This evidence concerns the gene SOAT1 and cancer.