They demonstrate that, following the initial transient adhesive interactions between metastatic tumor cells and vascular endothelium mediated by cancer-associated TF-Ag and endothelium expressed Gal-3, endothelial integrin α3β1 physically associates with TF-Ag/Gal-3 complexes at the endothelial cell surfaces and stabilizes tumor/endothelial cell adhesion. The gene discussed is RENBP; the disease is cancer.