LGALS3 and cancer: Subsequently, it has been demonstrated that, while cancer cell expressed Gal-3 is involved in regulation of tumor cell apoptosis and homotypic aggregation [9, 21, 24, 25] and may even serve as a complementary serum marker in prostate cancer [26], it is endothelium expressed Gal-3 that mediates metastatic cell adhesion to the endothelium via interactions with cancer associated TF-Ag [9, 17-20].