TF and neoplasm: As our TF-Gold pull-down experiments revealed, in addition to Gal-3 and α3β1 integrin, the presence of the Src kinase (a principal signal transduction molecule acting downstream of α3β1), as well as of 7 other proteins mapping onto focal adhesion pathway (Fig. 1) in TF-Au samples, our next question was whether tumor/endothelial cell adhesive interactions activate major signaling pathways in endothelial cells downstream of α3β1 integrin.