Moreover, patients with high histological grade (Supplementary Fig. S5D, P = 0.248) or estrogen receptor-negative (Supplementary Fig. S5F, P = 0.278), c-erbB-2-positive (Supplementary Fig. S5H, P = 0.244), p53-negative (Supplementary Fig. S5I, P = 0.072), or Ki67-positive (Supplementary Fig. S5J, P = 0.145) breast cancer showed a trend for poor overall survival, although not statistically significant. Here, ESR1 is linked to breast cancer.