In addition to the higher tumorigenicity and metastasis as evident in studies of limited dilution, serial xenotransplantation and intravenous injection of the cells in NOD/SCID Il2rγ-/− recipient mice, we also demonstrated that CD61 status is a prognostic factor for predicting the overall survival of the lung cancer patients as well as the patients with breast cancer or ovarian cancer. The gene discussed is ITGB3; the disease is breast cancer.