With most CSC studies focusing on the four Yamanaka factors (Oct4, Sox2, Klf4, and c-Myc, hereafter referred to as Myc), which are essential for the stemness of embryonic stem cells (ESCs), stem cells (SCs), induced pluripotent cells (iPSCs), and CSCs, the potential role of extracellular stimuli, such as sub-lethal stress induced by As3+, in CSC induction has been understudied, and its relevance to cancer development has remained obscure. This evidence concerns the gene MYC and cancer.