By supporting the large number of client proteins involved in multiple cancer related pathways, Hsp90 is involved in the regulation of many of the “hallmarks of cancer”, namely sustaining proliferative signalling, resisting cell death, evading growth suppressors, inducing angiogenesis, enabling replicative immortality, invasion and metastasis, and emerging hallmarks including deregulating cellular energetic and avoiding immune destruction [110, 111]. This evidence concerns the gene HSP90AB1 and cancer.