If we assume that these variants are disease-associated and occur at a similar frequency for all groups with schizophrenia, we would expect to find the more common NPAS3 alleles in 45/150 (~7/120 homozygotes) in the cohort recruited at the location of the neuroimaging arm cohort, and detect rare NPAS3 variants in 2 to 5 individuals. This evidence concerns the gene NPAS3 and schizophrenia.