Further work is needed to elucidate the role of IFITM5 in osteoblast differentiation and matrix mineralisation to understand the mechanism by which the c.-14C > T mutation results in OI type V. Furthermore, the elucidation of the mechanism resulting in “explosive” hyperplastic callus formation may lead to a specific pharmacological intervention to prevent progression of this devastating manifestation. This evidence concerns the gene IFITM5 and osteogenesis imperfecta type 5.