Several early-phase clinical trials in the U.S. and Europe are currently evaluating mTOR inhibition (e.g., sirolimus, temsirolimus, everolimus) in combination with cytotoxic chemotherapy in adults with de novo AML (NCT01611116, NCT01154439, NCT01822015, NCT01869114) (33). Here, MTOR is linked to acute myeloid leukemia.