FLT3 and acute myeloid leukemia: Constitutive activation of the phosphatidylinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signal transduction cascade has been well-documented in AML, and PI3K/Akt/mTOR signaling activation often occurs as a downstream sequela of FLT3-ITD alterations (85–87).