PROM1 and brain neoplasm: PPARγ agonists have also been found to inhibit the expansion and proliferation of CD133+ brain tumors stem cells (BTSCs, also termed Brain Tumor Initiating Cells) by inhibiting the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway using ciglitazone, 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), and all-trans retinoic acid (ATRA) (26, 29).