Shlipak et al. [13] using a cohort of 4663 participants in the Cardiovascular Health Study (CHS) [14, 15] recruited from four U.S. communities studied cystatin C as a prognostic biomarker of death, cardiovascular disease, and incidental chronic kidney disease in people > 65 years without previous renal disease. This evidence concerns the gene CST3 and cardiovascular disorder.