Moreover, RES induced autophagy in human U251 glioma cells [34], decreased the intracellular reactive oxygen species level, which correlated with the induction of caspase-8 and caspase-3 cleavage in human colon cancer cells [35] and induced apoptosis in patients with chronic myeloid leukemia cells [36]. This evidence concerns the gene CASP8 and chronic myelogenous leukemia, BCR-ABL1 positive.