Moreover, RES induced autophagy in human U251 glioma cells [34], decreased the intracellular reactive oxygen species level, which correlated with the induction of caspase-8 and caspase-3 cleavage in human colon cancer cells [35] and induced apoptosis in patients with chronic myeloid leukemia cells [36]. Here, CASP3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.