Moreover, RES induced autophagy in human U251 glioma cells [34], decreased the intracellular reactive oxygen species level, which correlated with the induction of caspase-8 and caspase-3 cleavage in human colon cancer cells [35] and induced apoptosis in patients with chronic myeloid leukemia cells [36]. The gene discussed is CASP8; the disease is central nervous system cancer.