NFE2L2 and amyotrophic lateral sclerosis: S(+)-apomorphine, a nontoxic Nrf2 activating molecule, demonstrated not only CNS penetrance, Nrf2 induction, and significant attenuation of motor dysfunction in SOD1G93A transgenic mice, but also a reduced pathological oxidative stress and an improved survival following an oxidative insult in fibroblasts from ALS patients [56].