Although in our study we did not find any significant correlation between promoter's Nrf2 SNPs and ALS and between these SNPs and the assessed peripheral oxidative stress biomarkers, the abovementioned bulk of literature, in showing Nrf2 involvement in ALS, suggests to further investigate this field, possibly analyzing the entire Nrf2 gene, as well as other molecular pathways correlated with it, as susceptibility factors in ALS. This evidence concerns the gene NFE2L2 and amyotrophic lateral sclerosis.