Indeed, experiments in an orthotopic mouse model of pancreatic cancer suggest that IL-13Rα2 is an important mediator of the pro-tumor effects of IL-13, including activation of AP-1 growth signals, production of immunomodulatory cytokines such as TGF-β, and promotion of metastasis (58, 142). The gene discussed is TGFB1; the disease is familial pancreatic carcinoma.