This content is highly thrombogenic and produces activation of platelets causing the formation of local thrombus occluding the artery or embolising and resulting in ischemic stroke or myocardial infarction (Erlinge and Burnstock, 2008) Pinheiro et al. demonstrated using human subcutaneous fibroblast that the release of histamine induces an increase in intracellular Ca2+ resulting in the release of ATP via Panx-1 hemichannels (Pinheiro et al., 2013). The gene discussed is PANX1; the disease is ischemic stroke.