Among “new-for-stroke,” pro-angiogenic transcription factors, we noted the constant and robust upregulation (fourfold to sixfold) of hematopoietically expressed homeobox (Hhex), runt-related transcription factor 1 (Runx1), and the SRY-box containing gene 7 (Sox7), all of them previously unknown to stroke models. The gene discussed is HHEX; the disease is stroke disorder.