Tissue hypoxia activates Vegfa and Vegfc expression as well as the expression of other transcripts encoding angiogenic factors such as angiopoietin-2 (Angpt2) and the “new-for-stroke,” angiopoietin-like 2 (Angptl2), angiopoietin-like 4 (Angptl4), and the endothelial and SMC chemoattractant Cxcl1 and its receptor Cxcr2, on EC. The gene discussed is ANGPTL4; the disease is stroke disorder.