CIB1 is a calcium and integrin-binding protein-1 that is essential for proper EC signaling and function such as migration, proliferation, and nascent tubule formation, and therefore is critical in ischemia-induced angiogenesis in the retina, as well as ischemia-induced adaptive angiogenesis (Zayed et al., 2007). This evidence concerns the gene CIB1 and ischemia.