In particular, we noted the mirrored expression of Angptl4, Cib1 and Col8a1, Eng, Lef1, Nrp1, Pecam, Tpm4 transcripts, suggesting that delayed cellular proliferation in conjunction with a delayed secretion of proper migrating substrates is the main cause of delayed sprouting angiogenesis in the aged rat brains after stroke. Here, ENG is linked to stroke disorder.