Our studies also suggest that the new “stroke genes” Fnbl5, Fndc1, Pcolce, Scpep1, and Igfbp7 induce EC-lumen formation (Newman et al., 2011) by increasing the stiffness of the ECM and increasing BV elasticity (Pshezhetsky and Hinek, 2009). The gene discussed is FNDC1; the disease is Stroke.