Given the increasing consensus that multiple mechanisms during aging may synergistically contribute to AD pathogenesis and cognitive decline, it is important to continue investigating the role of combination therapies in modulating synaptic plasticity, including BST and LTP, mitochondrial function, oxidative stress, and inflammation in models of AD and aging, including experimental models of amyloid, tau, chronic inflammation, and oxidative stress. Here, MAPT is linked to Alzheimer disease.