Interestingly, disruption of the T-type calcium channel activity has been reported to strongly alter physiological induction and maintenance of LTP in the hippocampus, visual cortex and cerebellum (Yoshimura et al., 2008; Chen et al., 2012; Ly et al., 2013) and mutations of the human cacna1h gene have been associated with autism spectrum disorder (ASD; Splawski et al., 2006). Here, CACNA1H is linked to autism spectrum disorder.