This view is corroborated by a reported genetic linkage between chromosomal loci for the Nogo-A or its receptor and susceptibility to schizophrenia (Novak et al., 2002; Sinibaldi et al., 2004; Tan et al., 2005; Hsu et al., 2007; Budel et al., 2008; Voineskos, 2009; Jitoku et al., 2011). The gene discussed is RTN4; the disease is schizophrenia.