RTN4 and schizophrenia: In mouse and rat models, Nogo-A-deficient animals exhibit symptoms such as disrupted sensorimotor gating and latent inhibition, deficits of memory, cognitive flexibility, and social behavior (Willi et al., 2010; Tews et al., 2013; Petrasek et al., 2014, the present work), which are characteristic for schizophrenia models, and are considered analogous to cognitive and negative symptoms in humans (Bubenikova-Valesova et al., 2008b; Jones et al., 2011).