CRH and psychiatric disorder: A dysregulated CRH/CRHR1 system is suggested to be one of the most common disturbances associated with psychiatric disorders (Arborelius et al., 1999; Müller et al., 2003; de Kloet et al., 2005; Ressler et al., 2010; Griebel and Holsboer, 2012) and critically involved in both the regulation of anxiety-related behavior and the reactivity of the hypothalamic-pituitary-adrenal axis (Reul and Holsboer, 2002).