MAPT and Alzheimer disease: An increase in oxidative DNA (Brasnjevic et al., 2008; Coppedè and Migliore, 2009; Bradley-Whitman et al., 2014) and RNA (Lovell et al., 2011; Nunomura et al., 2012) damage occurs in a subset of vulnerable neurons that exhibit Tau pathology during the early stages of AD.