More importantly, amyloid-like fibrils of human apo-SOD1SH retain their seeding activity in the intracellular environment; transduction of those human SOD1 fibrils into cultured cells (mouse neuroblastoma, Neuro2a) has been shown to trigger the aggregation of stably-transfected human SOD1 (Furukawa et al., 2013). The gene discussed is SOD1; the disease is neuroblastoma.