MTOR and epilepsy: It is notable, therefore, that hyperactivation of mTOR signaling is present in acute seizure (Zhang and Wong, 2012), status epilepticus (Okamoto et al., 2010; Macias et al., 2013), traumatic brain injury (Chen et al., 2007), hypoxia (Talos et al., 2012; Sun et al., 2013), and in vitro (Berdichevsky et al., 2013) models of epilepsy.