MTOR and epilepsy: Work by Buckmaster and Wen (2011) demonstrated that inhibiting mTOR with rapamycin in the pilocarpine model of epilepsy can reduce axon sprouting of somatostatin-expressing GABAergic interneurons, raising the possibility that mTOR-mediated sprouting in epilepsy may exert both pro-excitatory and homeostatic effects, depending on the cell type affected.