The resistance of our novel cell line could be that it is not an EWS-FLI1 fusion type, as the most common subtype, type 1, being associated with a favorable prognosis Ewing sarcomas with EWS-FLI1 and EWS-ERG gene fusions has similar clinical phenotypes supporting the notion that our cell line is perhaps representative of the less favorable subtypes, and perhaps the clinical result of our study could translate to other the more aggressive resistant types of EWS [17–19]. The gene discussed is EWSR1; the disease is Ewing sarcoma.