In addition to the close MuRF1 homologues MuRF2 and MuRF3, these classes include proteins such as the Opitz syndrome protein Midline-1 (MID1) and its homologue Midline-2 (MID2), the brain-specific TRIM9 that is seemingly linked to neuronal dysfunction in dementia, and Harprin (TRIM36), thought to regulate the acrosome reaction in sperm during fertilization. The gene discussed is MID2; the disease is dementia.