Triple Abs positivity (category I) defined by the presence of LA and high titres of IgG or IgM aCL > 40 GPL/MPL and IgG or IgM anti-β2GPI > 99th percentile antibodies was identified in ten patients with APS (14.28 %), while double positivity (also category I) in 12 cases of confirmed APS—17.14 %. Here, CD40LG is linked to autoimmune polyendocrinopathy.