MUC4 and in situ carcinoma: MUC4 expression was significantly downregulated in CIS from TMA (N = 4, mean H-score 0, table 3) as well as in case of tissue sections (N = 10; mean intensity 0.3±0.1; p = 0.02 and mean H-score 0.12±0.06) compared to the non-neoplastic urothelium (Fig. 3D).