MUC4 expression was significantly down-regulated in carcinoma cells compared to the non-neoplastic urothelium (mean H-score in the non-neoplastic bladder urothelium and UC being 2.54±0.21 [p<0.0001], and 0.47±0.05 respectively) (data from TMA). The gene discussed is MUC4; the disease is carcinoma.