Using an integrated, whole-body approach, stable isotope tracers to differentiate between changes in hepatic and peripheral insulin sensitivity of glucose uptake, body composition analysis using magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to investigate changes in body fat depot distribution, and a meal tolerance test (MTT) combined with arterio-venous (A-V) sampling across muscle tissue, for the first time we investigated the efficacy of increasing RS intake to achieve total fiber intakes above the GDA in individuals with T2DM. The gene discussed is INS; the disease is type 2 diabetes mellitus.