Plasma CgA and derived peptides are now commonly used as diagnostic and prognosticmarkers or to monitor the response to pharmacotherapeutic intervention in severaldiseases, such as endocrine tumors, heart failure, hypertension, and neurodegenerativeand neuropsychiatric diseases (e.g., depression, schizophrenia, and bipolar disease)(50, 51, 52, 53) (Fig. 2B). Here, CGA is linked to heart failure.