CGA and early-onset autosomal dominant Alzheimer disease: In particular, decreased CgA levels have been detected in thecerebrospinal fluid of canonical, but not late-onset type II Alzheimer's disease,patients (65), and decreased level ofvasostatin is characteristically observed in a cohort of patients with Alzheimer'sdisease compared with those suffering from frontotemporal dementia and healthycontrols (66).