CGA and systemic inflammatory response syndrome: Serum CgA has been used as an early biomarker of disease severity in patientsadmitted with systemic inflammatory response syndrome (63), whereas a relation between TNFα and CgA has beendemonstrated in rheumatoid arthritis (64).Stress situations are considered as a significant predisposing factor for immunediseases, and CgA levels have been related to the onset and progression ofperiodontal diseases.