In an experimental plan primarily designed to identify key herbs and compounds responsible for the neuroprotective effects of HLJDT in an in vitro AD model, N2aSwedAPP cells, we unexpectedly found that RS alone and HLJDT instead strongly increased Fl-APP, pAPPThr668, CTFs, sAPPs and Aβ (Figure 3D and 4A). The gene discussed is APP; the disease is Alzheimer disease.