NOTCH3 and leukemia: In the study, we also found that the expression level of CRIF1 increased when Notch3 was downregulated, and previous study in our lab found that CRIF1 might be associated with the cell cycle arrest of leukemia cells [28], and it might interact with CDK2 to regulate bone marrow microenvironment-induced G0/G1 arrest of leukemia cells(data not shown).