BDNF and psychiatric disorder: According to the fact that BDNF binding to TrkB receptors elicits several intracellular signaling cascades that mainly impact neuronal outcome positively [52], t-PA administration or interventions aimed at increasing t-PA activity such as physical exercice [32] could represent an interesting strategy in various neurological and psychiatric disorders associated with low level of BDNF and/or requiring an overproduction of this neurotrophin.