Deletion of the Slo3 gene abolishes IKSper (Santi et al., 2010; Zeng et al., 2011, 2013); male Slo3−/− mice are infertile due to defects in sperm motility (Santi et al., 2010; Zeng et al., 2011), osmoregulation (Santi et al., 2010; Zeng et al., 2011), and acrosomal exocytosis (Santi et al., 2010). This evidence concerns the gene KCNU1 and Infertility.