VDR and colorectal carcinoma: In our study of 1895 CRC cases and 2806 controls nested within three prospective cohorts, we did not observe statistically significant evidence for interaction between CRC genetic markers, including the 3 CRC SNPs identified in a prior CHiP-seq analysis as being adjacent to VDR-DNA binding sites, and plasma 25(OH)D on CRC risk, despite observing an increased risk for CRC associated with GRSs and an inverse association between circulating 25(OH)D levels and CRC.