IL6 and malignant colon neoplasm: There are 14 oncogenic mutations (from the COSMIC database [28,83]) that correspond to residues on the binding interfaces of IL-6–IL-6R–gp130 hexameric complex (Figure 8) and these mutations are related mostly to colon cancer (7 mutations), and also endometrial (2), liver (2), lung (1), breast (1) and stomach (1) cancers.