The NF-κB pathway is often activated in uveal melanoma and miR-9 was demonstrated to directly modulate NF-κB expression and also that of its downstream targets MMP-2, MMP-9 and vascular endothelial growth factor (VEGF)-a, which are all down regulated upon overexpression of miR-9 [65]. This evidence concerns the gene NFKB1 and uveal melanoma.