Also, miRs-21 and -10b were show to be significantly elevated in glioblastoma multiforme (GBM), and the experimental inhibition of these miRs in glioblastoma cells led to a significant decrease in MMP-2, EGFR, RhoC expression, and a concomitant increase in the tumor suppressors Pdcd4, tropomyosin (TPMI) and HoxD. The gene discussed is MMP2; the disease is neoplasm.