MiR-451 was found to directly impact glioblastoma cell proliferation, invasion, and apoptosis by down regulating the expression of Akt1, CyclinD1, MMP-2, MMP-9 and B-Cell CLL/lymphoma 2 (Bcl-2), however, no direct interaction of any of these mRNAs were found. This evidence concerns the gene AKT1 and glioblastoma.