In breast cancer, the transmembrane heparan sulfate proteoglycan (syndecan-1) has been linked to poor outcomes and MMP-2 was found amongst several other genes to be overexpressed in syndecan-1 deficient cells, with miR-10b to proven contribute to this effect by directly interacting with the 3' UTR of syndecan-1 [115]. This evidence concerns the gene SDC1 and breast cancer.