Note, however, that the increases in SHBG and serum estrogens with CEE use are highly correlated (for example, correlations (95% CIs) of 0.73 (0.66, 0.79) between (log-transformed) estradiol and estrone changes; and 0.59 (0.59, 0.67) between estrone and SHBG changes in the control group women) making it challenging to distinguish among the changes in specific sex hormones in relation to breast cancer risk. The gene discussed is SHBG; the disease is breast cancer.