Waknine-Grinberg et al.[22] and Bucher et al.[9] demonstrated that S. mansoni co-infected with P. berghei offered protection against cerebral malaria, while Lyke et al.[23] and Thigpen et al.[24] showed that Schistosoma haematobium infection decreased Tregs and Plasmodium parasitaemia, combined with increased IFN-γ and IL-2 during malaria infection. The gene discussed is IL2; the disease is urinary schistosomiasis.