Of particular interest are studies demonstrating that: (1) neuronal death in the hippocampal CA1 region was much more extensive in p53+/+ than in p53-/- mice subjected to transient global ischemia[63], and (2) transient focal ischemia induced by tMCAo led to significant ischemic damage in p53+/+ but not in p53+/- mice[64]. Here, TP53 is linked to ischemia.