TNF and rheumatoid arthritis: The anti-CD20 monoclonal antibody rituximab (RTX) was licensed in 2006 in combination with methotrexate (MTX) for the treatment of severe, active rheumatoid arthritis (RA) in adult patients with an inadequate response to disease-modifying antirheumatic drugs (DMARDs) including one or more tumour necrosis factor (TNF) inhibitors.