Preliminary histopathological analysis with some control- and WT-injected HIII female mice (3 animals/group) indicates that the WT Hsp65 inoculation results in a widespread chronic hepatitis, spleen hyperplasia, and, unlike LIII female, higher degree of nephrosis and chronic nephritis with inflammatory infiltration of plasma cells, macrophages and lymphocytes (data not shown), characteristics also present in human lupus nephritis [66]. The gene discussed is HSPD1; the disease is nephrosis.