Based on the immune alterations observed in the aging process, the reports of higher incidence of chronic-degenerative processes in elders [14,43] and the deleterious effect of M. leprae Hsp65 administration on murine lupus and autoimmune uveitis [35,38], we evaluated the interference of WT Hsp65 administration on survival time and correlation with antibody production in HIII and LIII mice. This evidence concerns the gene HSPD1 and systemic lupus erythematosus.