Additionally, Mcmanus et al. reported that treatment with the antioxidant MitoQ (mitoquinone mesylate) was effective in the prevention of cognitive impairment, oxidative stress, Aβ deposition, astrogliosis, synaptic loss, and caspase activation in 3xTg-AD mice, which express the Swedish mutation and also show tau-related pathology as observed in AD patients [140]. The gene discussed is MAPT; the disease is Alzheimer disease.