It was shown that the association between activity of MMP-2 in tumor and presence of DTCs in BM, in particular MMP-2 activity was 9.2 ± 5.1 μg/g tissue in patients with DTCs in BM whereas MMP-2 activity, was 4.1 ± 2.8 μg/g in patients without DTCs in BM (P < 0.05). This evidence concerns the gene MMP2 and neoplasm.