Additionally, because of the paucity of information regarding MMP24 and MMP25, more analysis is required to determine their function during the progression of GC; it is equally important to understand whether the expression of MMP-14 and TIMP-3 is involved with some activation mechanism of other MMPs, as has been reported previously for other members of the family of membrane-type MMPS and TIMPs. This evidence concerns the gene MMP25 and gastric cancer.