MMP2 and metastatic malignant neoplasm in the lymph nodes: Moreover, Allgayer and collaborators report a significant correlation has been detected between the staining intensity of MMP-2 with distant metastasis and with diffuse type GC (Lauren classification); however, there is no correlation with depth of tumoral infiltration (stage T), lymph node metastasis (stage N), infiltration of the blood vessels, Union for International Cancer Control (UICC) and Bormann classifications [37].