By investigating the effects of AnxA1 deficiency on the fibrogenic evolution of experimental NASH, we observed that the fibrosis markers, pro-collagen-1α, α-SMA, and TIMP-1, were higher in MCD-fed AnxA1 KO mice than in WT animals (Fig. 6). This evidence concerns the gene ACTA1 and metabolic dysfunction-associated steatohepatitis.