LGALS3 and metabolic dysfunction-associated steatohepatitis: The beta-galactoside-binding lectin, galectin-3, can direct myofibroblast activation in fibrotic livers and has been associated with the pathogenesis of NASH.18,19 In our experiments, liver galectin-3 expression was up-regulated in WT mice with advanced NASH and even more in AnxA1 KO mice which, at the 8-week time point had a hepatic content of galectin-3 2-fold higher than WT mice (Fig. 7).