A further evaluation of AnxA1 mRNA levels in 28 liver biopsies from NAFLD/NASH patients evidenced that AnxA1 expression was not related to the degree of IR or severity of liver injury (not shown), but inversely correlated with extension of fibrosis (r = −0.59; P < 0.003). This evidence concerns the gene ANXA1 and metabolic dysfunction-associated steatohepatitis.