Recently, Cooray et al. unveiled an AnxA1-specific FRP2/ALX proresolving signal pathway involving p38MAPK, MAPKAPK1/2, and heat shock protein 27, leading to generation of IL-10.17 In our experiments with isolated macrophages from NASH livers, down-modulation of iNOS and IL-12p40 is associated with a 2-fold rise in IL-10 expression; importantly, pharmacological inhibition of p38MAPK affects, in opposite ways, AnxA1-induced IL-10 stimulation and suppression of M1 polarization. This evidence concerns the gene NOS2 and metabolic dysfunction-associated steatohepatitis.