ANXA1 and metabolic dysfunction-associated steatohepatitis: The homeostatic functions of AnxA1 are mediated by FPR2/ALX, a G-protein-coupled receptor that is shared with other proresolving lipid mediators, including lipoxin A4 and resolvin D1,23,24 as well as with the proinflammatory protein, serum amyloid A, and cathelicidin LL-37.25,26 We observed that in vivo macrophage responses to endogenous AnxA1 become appreciable when FPR2/ALX is overexpressed in advaced NASH.