However, the 38 % reduction in basal insulin requirements in both CSII and MDI-treated patients with type 1 diabetes and 50 % reduction in total insulin requirements in MDI-treated patients are less than the overall 79 % reduction of insulin therapy previously observed in studies of type 2 diabetes patients, although this reduction was reported for a mean follow-up of 19.7 months [16]. This evidence concerns the gene INS and type 1 diabetes mellitus.