MYCN and neuroblastoma: The aim of our study was to demonstrate that quantitation of the transverse relaxation rate, R2*, and changes in R2* induced by breathing 100% oxygen, ΔR2*oxygen-air, could discriminate between tumors arising in Th-ALKF1174L/Th-MYCN and Th-MYCN mice, and that intrinsic susceptibility MRI could thus potentially provide a non-invasive and clinically-translatable method to help identify children, presenting MYCN-amplified neuroblastoma harboring the ALKF1174L mutation.