Here we examined representative genes of these respective pathways, namely BNP, a clinically used neuro-hormonal marker of heart failure induced by wall stress, the glucose transporter Glut1, an hypoxia-induced gene upregulated in cardiac ischemia22, 23 and Periostin, a matricellular protein promoting matrix organization following cardiac injury under the regulation of Angiotensin II and TGFβ [29], [30]. Here, NPPB is linked to heart failure.