The average sera concentrations of MCP-1 and MIP-1β were 295 pg/ml and 47 pg/ml, respectively (for healthy volunteers), 454 pg/ml and 220 pg/ml, respectively (for ID-IBS), 467 pg/ml and 216.2 pg/ml, respectively (for PI-IBS). The gene discussed is CCL4; the disease is irritable bowel syndrome.