Although the exact mechanism is yet to be fully elucidated, it is widely accepted that increased levels of cytokines such as interleukin-6 (IL-6), tumour necrosis factor (TNF) and other factors such as zinc-alpha2-glycoprotein (ZAG) trigger the catabolic events that promote lipid depletion from fat depots and asthenia [6], [7], [8]. This evidence concerns the gene IL6 and asthenia.