NPPB and coronary artery disorder: Moreover, in ESRD patients receiving long-term dialysis, BNP and NT-proBNP levels are strongly associated with the severity of LV hypertrophy and systolic dysfunction [6], [26], [27], [28], [29], [30], and their elevation also reflects the presence of myocardial ischemia and is indicative of the severity of coronary artery disease [31].